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A genome-wide search for linkage to asthma

Item Type:Article
Title:A genome-wide search for linkage to asthma
Creators Name:Wjst, M. and Fischer, G. and Immervoll, T. and Jung, M. and Saar, K. and Rueschendorf, F. and Reis, A. and Ulbrecht, M. and Gomolka, M. and Weiss, E.H. and Jaeger, L. and Nickel, R. and Richter, K. and Kjellman, N.I.M. and Griese, M. and von Berg, A. and Gappa, M. and Riedel, F. and Boehle, M. and van Koningsbruggen, S. and Schoberth, P. and Szczepanski, R. and Dorsch, W. and Silbermann, M. and Loesgen, S. and Scholz, M. and Bickeboller, H. and Wichmann, H.E.
Abstract:Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, the basis for familial occurrence of asthma remains unclear. Previous genome screens for atopy in British/Australian families and for asthma in different American populations showed inconsistent results. We report a sib pair study of a sample of 97 families, including 415 persons and 156 sib pairs. Following an extensive clinical evaluation, all participants were genotyped for 351 polymorphic dinucleotide markers. Linkage analysis for asthma identified four chromosomal regions that could to be linked to asthma: chromosome 2 (at marker D2S2298, P = 0.007), chromosome 6 (around D6S291, lowest P = 0.008), chromosome 9 (proximal to D9S1784, P = 0.007), and chromosome 12 (D12S351, P = 0.010). These linkage regions could be reproduced for all loci by analysis of total or specific immunoglobulin E (minimum P values at these regions were 0. 003, 0.001, 0.010, and 0.015, respectively).
Keywords:Asthma, Human, Pair 12 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 9 Chromosomes, Family Health, Genetic Markers, Human Genome, Germany, Immunoglobulin E, Linkage, Phenotype, Radioallergosorbent Test
Publisher:Academic Press
Page Range:1-8
Date:15 May 1999
Official Publication:https://doi.org/10.1006/geno.1999.5806
PubMed:View item in PubMed

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