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Growth hormone therapy in heart failure

Item Type:Article
Title:Growth hormone therapy in heart failure
Creators Name:Strohm, O. and Friedrich, M.G. and von Harsdorf, R. and Osterziel, K.J. and Dietz, R.
Abstract:Clinical and experimental data in animals and patients with endstage heart failure due to dilated cardiomyopathy or ischemic heart disease suggest a beneficial role of growth factors like human recombinant growth hormone or insulin-like growth factor I. Their cardiac effects are an increase in myocardial mass and a decrease in systolic wall stress. Based on the results of animal studies and of preliminary studies in patients with dilated cardiomyopathy, double-blind and placebo-controlled studies have proven the increase in myocardial mass and a significant reduction of left ventricular wall stress, as demonstrated by magnetic resonance imaging.The risk of the additional therapy with human growth factors in this high-risk group of patients with a high mortality is justified, if this new approach becomes a possible alternative to cardiac transplantation or a bridge toward transplantation.If future randomized studies in larger patient groups with an individualized substitution therapy with growth hormone and/or IGF-I can demonstrate a beneficial effect on mortality and morbidity, this new therapeutic approach could become an attractive alternative in these high-risk patients.
Keywords:Heart Failure, IGF-I, Growth Hormone, Dilated Cardiomyopathy, Review
Source:Zeitschrift fuer Kardiologie
Number:Suppl 3
Page Range:S40-S46
Date:October 1999
Official Publication:https://doi.org/10.1007/s003920050587
PubMed:View item in PubMed

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