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Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells

Item Type:Article
Title:Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells
Creators Name:Grosche, J. and Matyash, V. and Moeller, T. and Verkhratsky, A. and Reichenbach, A. and Kettenmann, H.
Abstract:Astrocytes are considered a reticulate network of cells, through which calcium signals can spread easily. In Bergmann glia, astrocytic cells of the cerebellum, we identified subcellular compartments termed 'glial microdomains'. These elements have a complex surface consisting of thin membrane sheets, contain few mitochondria and wrap around synapses. To test for neuronal interaction with these structures, we electrically stimulated parallel fibers. This stimulation increased intracellular calcium concentration ([Ca2+]i) in small compartments within Bergmann glial cell processes similar in size to glial microdomains. Thus, a Bergmann glial cell may consist of hundreds of independent compartments capable of autonomous interactions with the particular group of synapses that they ensheath.
Keywords:Astrocytes, Calcium, Cell Communication, Cerebellum, Electric Stimulation, Intracellular Membranes, Nerve Fibers, Neurons, Patch-Clamp Techniques, Signal Transduction, Synapses, Animals, Mice
Source:Nature Neuroscience
ISSN:1097-6256
Publisher:Nature Publishing Group (U.K.)
Volume:2
Number:2
Page Range:139-143
Date:1 February 1999
Official Publication:https://doi.org/10.1038/5692
PubMed:View item in PubMed

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