Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Neuronal calcium stores

Item Type:Review
Title:Neuronal calcium stores
Creators Name:Verkhratsky, A.J. and Petersen, O.H.
Abstract:Neuronal calcium stores associated with specialized intracellular organelles, such as endoplasmic reticulum and mitochondria, dynamically participate in generation of cytoplasmic calcium signals which accompany neuronal activity. They fulfil a dual role in neuronal Ca2+ homeostasis being involved in both buffering the excess of Ca2+ entering the cytoplasm through plasmalemmal channels and providing an intracellular source for Ca2+. Increase of Ca2+ content within the stores regulates the availability and magnitude of intracellular calcium release, thereby providing a mechanism which couples the neuronal activity with functional state of intracellular Ca2+ stores. Apart of 'classical' calcium stores (endoplasmic reticulum and mitochondria) other organelles (e.g. nuclear envelope and neurotransmitter vesicles) may potentially act as a functional Ca2+ storage compartments. Calcium ions released from internal stores participate in many neuronal functions, and might be primarily involved in regulation of various aspects of neuronal plasticity.
Keywords:Calcium, Calcium Signaling, Endoplasmic Reticulum, Mitochondria, Neurons, Animals
Source:Cell Calcium
ISSN:0143-4160
Publisher:Elsevier (The Netherlands)
Volume:24
Number:5-6
Page Range:333-343
Date:1 November 1998
Official Publication:https://doi.org/10.1016/S0143-4160(98)90057-4
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library