Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering

Item Type:	Article
Title:	Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering
Creators Name:	Schuster, S. and Dandekar, T. and Fell, D.A.
Abstract:	Rational metabolic engineering requires powerful theoretical methods such as pathway analysis, in which the topology of metabolic networks is considered. All metabolic capabilities in steady states are composed of elementary flux modes, which are minimal sets of enzymes that can each generate valid steady states. The modes of the fructose-2,6-bisphosphate cycle, the combined tricarboxylic-acid-glyoxylate-shunt system and tryptophan synthesis are used here for illustration. This approach can be used for many biotechnological applications such as increasing the yield of a product, channelling a product into desired pathways and in functional reconstruction from genomic data.
Keywords:	Biochemistry, Biotechnology, Elementary Flux Modes, Biochemical Networks, Metabolic Pathway Analysis, Metabolites, Pathway Engineering
Source:	Trends in Biotechnology
ISSN:	0167-7799
Volume:	17
Number:	2
Page Range:	53-60
Date:	1 February 1999
Official Publication:	https://doi.org/10.1016/S0167-7799(98)01290-6
PubMed:	View item in PubMed

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