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Conservation of gene order: a fingerprint of proteins that physically interact

Official URL:https://doi.org/10.1016/S0968-0004(98)01274-2
PubMed:View item in PubMed
Creators Name:Dandekar, T. and Snel, B. and Huynen, M. and Bork, P.
Journal Title:Trends in Biochemical Sciences
Journal Abbreviation:Trends Biochem Sci
Volume:23
Number:9
Page Range:324-328
Date:1 September 1998
Keywords:Comparative Genomics, Gene Order, Bacteria, Archaea, Genome Organization
Abstract:A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.
ISSN:0968-0004
Publisher:Elsevier (The Netherlands)
Item Type:Article

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