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Conservation of gene order: a fingerprint of proteins that physically interact

Item Type:Article
Title:Conservation of gene order: a fingerprint of proteins that physically interact
Creators Name:Dandekar, T. and Snel, B. and Huynen, M. and Bork, P.
Abstract:A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.
Keywords:Comparative Genomics, Gene Order, Bacteria, Archaea, Genome Organization
Source:Trends in Biochemical Sciences
ISSN:0968-0004
Publisher:Elsevier (The Netherlands)
Volume:23
Number:9
Page Range:324-328
Date:1 September 1998
Official Publication:https://doi.org/10.1016/S0968-0004(98)01274-2
PubMed:View item in PubMed

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