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Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

Official URL:https://doi.org/10.1016/S0962-8924(98)01359-2
PubMed:View item in PubMed
Creators Name:Birchmeier, C. and Gherardi, E.
Journal Title:Trends in Cell Biology
Journal Abbreviation:Trends Cell Biol
Volume:8
Number:10
Page Range:404-410
Date:1 October 1998
Keywords:Cell Behaviour, Cell Differentiation, Cell Motility, Scatter Factor, Hepatocyte Growth Factor (HGF), Met Receptor, Plasminogen-Related Growth Factors, Animals, Mice
Abstract:A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.
ISSN:0962-8924
Publisher:Elsevier (The Netherlands)
Item Type:Article

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