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Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila

Item Type:Article
Title:Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila
Creators Name:Chaboissiert, M.C. and Bucheton, A. and Finnegan, D.J.
Abstract:The I factor is a LINE-like transposable element in Drosophila. Most strains of Drosophila melanogaster, inducer strains, contain 10-15 copies of the I factor per haploid genome located in the euchromatic regions of the chromosome arms. These are not present in a few strains known as reactive strains. I factors transpose at low frequency in inducer strains but at high frequency in the female progeny of crosses between reactive and inducer flies. We have found that the activity of the I factor promoter is sensitive to the number of copies of the first 186 nucleotides of the I factor sequence, which constitutes the 5'-untranslated region. The activity of the I factor decreases as the copy number of this sequence increases.
Keywords:Transposition, Regulation, Cosuppression, Animals, Drosophila
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences (U.S.A.)
Volume:95
Number:20
Page Range:11781-11785
Date:29 September 1998
Official Publication:http://www.pnas.org/content/95/20/11781.abstract
PubMed:View item in PubMed

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