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Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder

Item Type:Article
Title:Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder
Creators Name:Sander, T. and Harms, H. and Dufeu, P. and Kuhn, S. and Hoehe, M.R. and Lesch, K.P. and Rommelspacher, H. and Schmidt, L.G.
Abstract:BACKGROUND: We tested the hypothesis that a functional biallelic repetitive element in the 5' regulatory region of the human serotonin transporter gene (SLC6A4) confers susceptibility to serotonin-related personality traits underlying alcohol dependence with dissocial behavior. METHODS: The association study was focused on 64 alcohol-dependent subjects with a dissocial personality disorder (according to ICD-10) who were derived from 315 German alcohol-dependent subjects. The Tridimensional Personality Questionnaire (TPQ) was applied to assess personality dimensions in 101 alcohol-dependent men, including 39 dissocial alcoholics. RESULTS: Our association analyses revealed a trend towards a higher frequency of the short (S) allele of the SLC6A4 polymorphism in dissocial alcoholics compared to 216 German controls (chi 2 = 2.81, df = 1, p = 0.094). Dissocial alcoholics carrying the S/S genotype exhibited significant lower scores of harm avoidance compared to those lacking it (U-test, p = 0.015). Significantly higher novelty seeking scores were obtained in dissocial alcoholics carrying the S allele relative to those lacking it (U-test, p = 0.021). CONCLUSIONS: Our tentative association findings in dissocial alcoholics suggest that the S allele of the 5' regulatory SLC6A4 polymorphism confers susceptibility to a temperamental profile of high novelty seeking and low harm avoidance that has been postulated to underlie dissocial (type-2) alcoholism according to Cloninger's neurogenetic theory of personality.
Keywords:Alcohol Dependence, Serotonin Transporter Gene, Dissocial Personality, Association, Genetics
Source:Biological Psychiatry
Page Range:908-912
Date:15 June 1998
Official Publication:https://doi.org/10.1016/S0006-3223(97)00356-9
PubMed:View item in PubMed

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