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| Item Type: | Article |
|---|---|
| Title: | Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder |
| Creators Name: | Sander, T., Harms, H., Dufeu, P., Kuhn, S., Hoehe, M.R., Lesch, K.P., Rommelspacher, H. and Schmidt, L.G. |
| Abstract: | BACKGROUND: We tested the hypothesis that a functional biallelic repetitive element in the 5' regulatory region of the human serotonin transporter gene (SLC6A4) confers susceptibility to serotonin-related personality traits underlying alcohol dependence with dissocial behavior. METHODS: The association study was focused on 64 alcohol-dependent subjects with a dissocial personality disorder (according to ICD-10) who were derived from 315 German alcohol-dependent subjects. The Tridimensional Personality Questionnaire (TPQ) was applied to assess personality dimensions in 101 alcohol-dependent men, including 39 dissocial alcoholics. RESULTS: Our association analyses revealed a trend towards a higher frequency of the short (S) allele of the SLC6A4 polymorphism in dissocial alcoholics compared to 216 German controls (chi 2 = 2.81, df = 1, p = 0.094). Dissocial alcoholics carrying the S/S genotype exhibited significant lower scores of harm avoidance compared to those lacking it (U-test, p = 0.015). Significantly higher novelty seeking scores were obtained in dissocial alcoholics carrying the S allele relative to those lacking it (U-test, p = 0.021). CONCLUSIONS: Our tentative association findings in dissocial alcoholics suggest that the S allele of the 5' regulatory SLC6A4 polymorphism confers susceptibility to a temperamental profile of high novelty seeking and low harm avoidance that has been postulated to underlie dissocial (type-2) alcoholism according to Cloninger's neurogenetic theory of personality. |
| Keywords: | Alcohol Dependence, Serotonin Transporter Gene, Dissocial Personality, Association, Genetics |
| Source: | Biological Psychiatry |
| ISSN: | 0006-3223 |
| Publisher: | Elsevier |
| Volume: | 43 |
| Number: | 12 |
| Page Range: | 908-912 |
| Date: | 15 June 1998 |
| Official Publication: | https://doi.org/10.1016/S0006-3223(97)00356-9 |
| PubMed: | View item in PubMed |
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