The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism

Item Type:	Article
Title:	The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism
Creators Name:	Willnow, T.E.
Abstract:	The low-density lipoprotein receptor gene family encompasses a class of endocytic receptors that exhibit structural similarities to the low-density lipoprotein receptor. Members of this gene family are present in both vertebrate and nonvertebrate species. The identification of naturally occurring mutations and the application of gene targeting to inactivate receptor genes enabled us to develop animal models to investigate the consequences of individual receptor defects in vivo. Analysis of these animal models revealed exciting new functions of lipoprotein receptors not only in systemic clearance of lipoproteins but also in other important biological processes including reproduction, brain development. and adipositas.
Keywords:	Chaperone, Chylomicron Remnants, Endocytosis, Hyperlipidemia, Holoprosencephaly, Animals, Chickens, Drosophila melanogaster, Mice, Rabbits
Source:	Journal of Molecular Medicine
ISSN:	0946-2716
Publisher:	Springer
Volume:	77
Number:	3
Page Range:	306-315
Date:	March 1999
Official Publication:	https://doi.org/10.1007/s001090050356
PubMed:	View item in PubMed

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