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Kinetics of GABAB receptor-mediated inhibition of calcium currents and excitatory synaptic transmission in hippocampal neurons in vitro

Item Type:Article
Title:Kinetics of GABAB receptor-mediated inhibition of calcium currents and excitatory synaptic transmission in hippocampal neurons in vitro
Creators Name:Pfrieger, F.W. and Gottmann, K. and Lux, H.D.
Abstract:The time courses of the gamma-aminobutyric acid type B (GABAB) receptor-mediated inhibition of excitatory synaptic transmission and of action potential-evoked calcium currents were studied in hippocampal neurons in vitro with step-like changes of a saturating baclofen concentration. Inhibition mediated by postsynaptic GABAB receptors was excluded pharmacologically. Both presynaptic inhibition and reduction of calcium currents developed and declined exponentially with similar time constants of about 0.2 and 3 s, respectively. The close correlation of the time courses indicates that fast, G protein-mediated depression of voltage-gated calcium channels and thus direct reduction of the presynaptic calcium influx may contribute to the GABAB receptor-induced inhibition of excitatory synaptic transmission in hippocampal neurons in vitro.
Keywords:Action Potentials, Baclofen, Calcium Channels, Cultured Cells, Electrophysiology, Mammalian Embryo, Evoked Potentials, GTP-Binding Proteins, Hippocampus, Kinetics, Neurons, Quinoxalines, GABA-B Receptors, Synaptic Transmission, Animals, Rats
Source:Neuron
ISSN:0896-6273
Publisher:Cell Press (U.S.A.)
Volume:12
Number:1
Page Range:97-107
Date:January 1994
Official Publication:https://doi.org/10.1016/0896-6273(94)90155-4
PubMed:View item in PubMed

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