Environmental trichlorfon and cluster of congenital abnormalities

Item Type:	Article
Title:	Environmental trichlorfon and cluster of congenital abnormalities
Creators Name:	Czeizel, A.E. and Elek, C. and Gundy, S. and Metneki, J. and Nemes, E. and Reis, A. and Sperling, K. and Timar, L. and Tusnady, G. and Viragh, Z.
Abstract:	Of 15 live births in one Hungarian village in 1989-90, 11 (73%) were affected by congenital abnormalities and 6 were twins. Of the 11, 4 had Down syndrome. Likely causes of such clusters (known teratogenic factors, familial inheritance, consanguinity) were excluded. A case-control study and environmental investigations pointed the finger of suspicion at the excessive use of trichlorfon at local fish farms. The content of this chemical was very high in fish (100 mg/kg) and several pregnant women, including all mothers of babies with Down syndrome, had consumed contaminated fish in the critical period for the congenital abnormalities observed.
Keywords:	Drug-Induced Abnormalities, Case-Control Studies, Cluster Analysis, Diseases in Twins, Down Syndrome, Food Contamination, Hungary, Pregnancy, Trichlorfon, Animals, Fishes
Source:	Lancet
ISSN:	0140-6736
Publisher:	Lancet
Volume:	341
Number:	8844
Page Range:	539-542
Date:	27 February 1993
Official Publication:	https://doi.org/10.1016/0140-6736(93)90293-P
PubMed:	View item in PubMed

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