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Cloning of two novel human importin alpha subunits and analysis of the expression pattern of the importin-alpha protein family

Item Type:Article
Title:Cloning of two novel human importin alpha subunits and analysis of the expression pattern of the importin-alpha protein family
Creators Name:Koehler, M. and Ansieau, S. and Prehn, S. and Leutz, A. and Haller, H. and Hartmann, E.
Abstract:The import of many proteins into the nucleus is mediated by the importin-alpha/beta heterodimer. While only one importin-beta gene has been found, several forms of importin-alpha have been described. In addition to the three human importin-alphas already identified, we report here the primary structure of two new human importin-alpha proteins. The five known human importin-alpha subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-alpha subfamilies are expressed in a variety of human tissues and mammalian cell lines.
Keywords:Nuclear Transport, Importin-{alpha}, Protein Expression, Nuclear Signaling, Animals, Rabbits
Source:FEBS Letters
ISSN:0014-5793
Publisher:Elsevier (The Netherlands)
Volume:417
Number:1
Page Range:104-108
Date:3 November 1997
Official Publication:https://doi.org/10.1016/S0014-5793(97)01265-9
PubMed:View item in PubMed

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