Structure/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily

Item Type:	Article
Title:	Structure/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily
Creators Name:	Bruemmendorf, T. and Rathjen, F.G.
Abstract:	Evidence is accumulating that axonal members of the Ig superfamily (IgSF) interact in a complex manner with other axonal Ig-like proteins and with proteins of the extracellular matrix. Studies investigating the structure/function relationships of these proteins have highlighted the importance of Ig-like domains near the amino terminus (N-proximal) as both necessary and sufficient for homophilic and heterophilic binding. Although efforts have been made in the past year to correlate the structure and neurite-outgrowth-promoting ability of axonal IgSF members, this work is still at an early stage.
Keywords:	Axons, Binding Sites, Cell Adhesion, Extracellular Matrix, Immunoglobulins, Integrins, Neural Cell Adhesion Molecules, Neurites, Neurons, Animals
Source:	Current Opinion in Neurobiology
ISSN:	0959-4388
Publisher:	Elsevier
Volume:	6
Number:	5
Page Range:	584-593
Date:	October 1996
Official Publication:	https://doi.org/10.1016/S0959-4388(96)80089-4
PubMed:	View item in PubMed

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