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Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma

Item Type:Article
Title:Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma
Creators Name:Dobner, T. and Wolf, I. and Emrich, T. and Lipp, M.
Abstract:Deregulation of the proto-oncogene MYC by specific chromosomal translocations has been shown to be essential but not sufficient for the development of Burkitt's lymphoma (BL). To identify other genes which either mark important steps in tumorigenesis or which reflect the cellular differentiation state of BL cells we have compared tumor cells to immortalized lymphoblastoid B cells by subtractive hybridization. We have identified a complementary DNA clone which encodes a novel member of the superfamily of GTP-binding (G) protein-coupled receptors, designated BLR1. The corresponding mRNA is expressed in BL and lymphatic tissues but not in other cell lines either of the B cell lineage or of other hematopoietic or non-hematopoietic origin. This exclusive expression of BLR1 and the oncogenic potential of this receptor class supports the hypothesis that BLR1 exerts a regulatory function in BL lymphomagenesis and/or B cell differentiation. Moreover, the protein sequence is highly related to that of receptors for the cytokine interleukin (IL)-8 and other neutrophil chemoattractants. We conclude that BLR1 may represent a potential candidate involved in the process of physiologic trafficking, cell-cell interactions, and activation of mature B lymphocytes in lymphatic tissues.
Keywords:Amino Acid Sequence, Base Sequence, Burkitt Lymphoma, Cell Differentiation, GTP-Binding Proteins, Molecular Sequence Data, Immunologic Receptors, Interleukin-8A Receptors
Source:European Journal of Immunology
ISSN:0014-2980
Publisher:Wiley (U.S.A.)
Volume:22
Number:11
Page Range:2795-2799
Date:1 November 1992
Official Publication:https://doi.org/10.1002/eji.1830221107
PubMed:View item in PubMed

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