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| Item Type: | Article |
|---|---|
| Title: | Comprehensive characterization of the viscoelastic properties of bovine submaxillary mucin (BSM) hydrogels and the effect of additives |
| Creators Name: | Rulff, H. and Schmidt, R.F. and Wei, L.F. and Fentker, K. and Kerkhoff, Y. and Mertins, P. and Mall, M.A. and Lauster, D. and Gradzielski, M. |
| Abstract: | This study presents a comprehensive characterization of the viscoelastic and structural properties of bovine submaxillary mucin (BSM), which is widely used as a commercial source to conduct mucus-related research. We conducted concentration studies of BSM and examined the effects of various additives, NaCl, CaCl(2), MgCl(2), lysozyme, and DNA, on its rheological behavior. A notable connection between BSM concentration and viscoelastic properties was observed, particularly under varying ionic conditions. The rheological spectra could be well described by a fractional Kelvin-Voigt model with a minimum of model parameters. A detailed proteomics analysis provided insight into the protein, especially mucin composition within BSM, showing MUC19 as the main component. Cryo-scanning electron microscopy enabled the visualization of the porous BSM network structure. These investigations give us a more profound comprehension of the BSM properties, especially those pertaining to viscoelasticity, and how they are influenced by concentration and environmental conditions, aspects relevant to the field of mucus research. |
| Source: | Biomacromolecules |
| ISSN: | 1526-4602 |
| Publisher: | American Chemical Society |
| Date: | 4 June 2024 |
| Official Publication: | https://doi.org/10.1021/acs.biomac.4c00153 |
| PubMed: | View item in PubMed |
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