![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
|
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB | |
![[img]](http://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supporting Information)
1MB |
| Item Type: | Article |
|---|---|
| Title: | IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota |
| Creators Name: | Röwekamp, I. and Maschirow, L. and Rabes, A. and Fiocca Vernengo, F. and Hamann, L. and Heinz, G.A. and Mashreghi, M.F. and Caesar, S. and Milek, M. and Fagundes Fonseca, A.C. and Wienhold, S.M. and Nouailles, G. and Yao, L. and Mousavi, S. and Bruder, D. and Boehme, J.D. and Puzianowska-Kuznicka, M. and Beule, D. and Witzenrath, M. and Löhning, M. and Klose, C.S.N. and Heimesaat, M.M. and Diefenbach, A. and Opitz, B. |
| Abstract: | IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild-type animals and that single-nucleotide polymorphisms in IL33 and IL1RL1 were associated with pneumococcal pneumonia in humans. The effect of IL-33 on S. pneumoniae infection was mediated by negative regulation of IL-22 production in innate lymphoid cells (ILCs) but independent of ILC2s as well as IL-4 and IL-13 signaling. Moreover, IL-33's influence on IL-22-dependent antibacterial defense was dependent on housing conditions of the mice and mediated by IL-33's modulatory effect on the gut microbiota. Collectively, we provide insight into the bidirectional crosstalk between the innate immune system and the microbiota. We conclude that both genetic and environmental factors influence the gut microbiota, thereby impacting the efficacy of antibacterial immune defense and susceptibility to pneumonia. |
| Keywords: | Pneumonia, Streptococcus Pneumoniae, Microbiota, IL-33, IL-22, Animals, Mice |
| Source: | Proceedings of the National Academy of Sciences of the United States of America |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Volume: | 121 |
| Number: | 22 |
| Page Range: | e2310864121 |
| Date: | 28 May 2024 |
| Official Publication: | https://doi.org/10.1073/pnas.2310864121 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
Download Statistics
Download Statistics
