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The diversity of the microbiome impacts chronic lymphocytic leukemia development in mice and humans

Item Type:Article
Title:The diversity of the microbiome impacts chronic lymphocytic leukemia development in mice and humans
Creators Name:Faitova, T. and Coelho, M. and Da Cunha-Bang, C. and Ozturk, S. and Kartal, E. and Bork, P. and Seiffert, M. and Niemann, C.U.
Abstract:The gut microbiota play a critical role in maintaining a healthy human body and their dysregulation is associated with various diseases. In this study, we investigated the influence of the gut microbiome diversity on chronic lymphocytic leukemia (CLL) development. Stool sample analysis of 59 CLL patients revealed individual and heterogeneous microbiome compositions, but allowed for grouping of patients according to their microbiome diversity. Interestingly, CLL patients with a lower microbiome diversity and an enrichment of bacteria linked to poor health suffered from a more advanced or aggressive form of CLL. In the Eµ-TCL1 mouse model of CLL, we observed a faster course of disease when mice were housed in high hygiene conditions. Shotgun DNA sequencing of fecal samples showed that this was associated with a lower microbiome diversity which was dominated by Mucispirillum and Parabacteroides genera in comparison to mice kept under lower hygiene conditions. In conclusion, we applied taxonomic microbiome analyses to demonstrate a link between the gut microbiome diversity and the clinical course of CLL in humans, as well as the development of CLL in mice. Our novel data serve as a basis for further investigations to decipher the pathological and mechanistic role of intestinal microbiota in CLL development.
Keywords:Animals, Mice
Publisher:Ferrata Storti Foundation
Date:9 May 2024
Official Publication:https://doi.org/10.3324/haematol.2023.284693
PubMed:View item in PubMed

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