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Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit

Item Type:Article
Title:Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit
Creators Name:Peng, Y. and Bjelde, A. and Aceituno, P.V. and Mittermaier, F.X. and Planert, H. and Grosser, S. and Onken, J. and Faust, K. and Kalbhenn, T. and Simon, M. and Radbruch, H. and Fidzinski, P. and Schmitz, D. and Alle, H. and Holtkamp, M. and Vida, I. and Grewe, B.F. and Geiger, J.R.P.
Abstract:The computational capabilities of neuronal networks are fundamentally constrained by their specific connectivity. Previous studies of cortical connectivity have mostly been carried out in rodents; whether the principles established therein also apply to the evolutionarily expanded human cortex is unclear. We studied network properties within the human temporal cortex using samples obtained from brain surgery. We analyzed multineuron patch-clamp recordings in layer 2-3 pyramidal neurons and identified substantial differences compared with rodents. Reciprocity showed random distribution, synaptic strength was independent from connection probability, and connectivity of the supragranular temporal cortex followed a directed and mostly acyclic graph topology. Application of these principles in neuronal models increased dimensionality of network dynamics, suggesting a critical role for cortical computation.
Keywords:Nerve Net, Neurons, Pyramidal Cells, Synapses, Animals, Rodentia
Publisher:American Association for the Advancement of Science
Page Range:338-343
Date:26 April 2024
Official Publication:https://doi.org/10.1126/science.adg8828
PubMed:View item in PubMed

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