Cell states in cancer: drivers, passengers, and trailers

Item Type:	Article
Title:	Cell states in cancer: drivers, passengers, and trailers
Creators Name:	Gargiulo, G. and Serresi, M. and Marine, J.C.
Abstract:	SUMMARY: Cancer is traditionally perceived through a genetic lens, with therapeutic strategies targeting oncogenic driver mutations. We advocate an overarching framework recognizing tumors as comprising driver, passenger, and trailer cell states: Tailoring therapies to simultaneously target driver genetics and cell states may enhance effectiveness and durability. SIGNIFICANCE: We redefine cancer progression by introducing a model that categorizes tumor cells into "driver," "passenger," and "trailer" phenotypes, expanding the focus on genetic aberrations to cellular behavior. This approach offers a roadmap to guide refining therapeutic strategies for more precise and durable cancer treatments that address tumor heterogeneity and plasticity.
Keywords:	Neoplasms
Source:	Cancer Discovery
ISSN:	2159-8274
Publisher:	American Association for Cancer Research
Volume:	14
Number:	4
Page Range:	610-614
Date:	4 April 2024
Official Publication:	https://doi.org/10.1158/2159-8290.CD-23-1510
PubMed:	View item in PubMed

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