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Cell states in cancer: drivers, passengers, and trailers

Item Type:Article
Title:Cell states in cancer: drivers, passengers, and trailers
Creators Name:Gargiulo, G., Serresi, M. and Marine, J.C.
Abstract:SUMMARY: Cancer is traditionally perceived through a genetic lens, with therapeutic strategies targeting oncogenic driver mutations. We advocate an overarching framework recognizing tumors as comprising driver, passenger, and trailer cell states: Tailoring therapies to simultaneously target driver genetics and cell states may enhance effectiveness and durability. SIGNIFICANCE: We redefine cancer progression by introducing a model that categorizes tumor cells into "driver," "passenger," and "trailer" phenotypes, expanding the focus on genetic aberrations to cellular behavior. This approach offers a roadmap to guide refining therapeutic strategies for more precise and durable cancer treatments that address tumor heterogeneity and plasticity.
Keywords:Neoplasms
Source:Cancer Discovery
ISSN:2159-8274
Publisher:American Association for Cancer Research
Volume:14
Number:4
Page Range:610-614
Date:4 April 2024
Official Publication:https://doi.org/10.1158/2159-8290.CD-23-1510
PubMed:View item in PubMed

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