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| Item Type: | Article |
|---|---|
| Title: | Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma |
| Creators Name: | Yalcin, F. and Haneke, H. and Efe, I.E. and Kuhrt, L.D. and Motta, E. and Nickl, B. and Flüh, C. and Synowitz, M. and Dzaye, O. and Bader, M. and Kettenmann, H. |
| Abstract: | Tumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and the murine RCAS-PDGFb high grade glioma model. Loss of GPNMB in the in vivo tumor microenvironment results in significantly smaller tumor volumes and generates a pro-inflammatory innate and adaptive immune cell microenvironment. The impact of host-derived GPNMB on tumor growth was confirmed in two distinct murine glioma cell lines in organotypic brain slices from GPNMB-KO and control mice. Using published data bases of human glioma, the elevated levels in TAMs could be confirmed and the GPNMB expression correlated with a poorer survival. |
| Keywords: | Microglia, Macrophage, GPNMB, RCAS, Experimental Glioma, Glioblastoma, CD44, Animals, Mice |
| Source: | Acta Neuropathologica Communications |
| ISSN: | 2051-5960 |
| Publisher: | BioMed Central |
| Volume: | 12 |
| Number: | 1 |
| Page Range: | 50 |
| Date: | 2 April 2024 |
| Official Publication: | https://doi.org/10.1186/s40478-024-01754-7 |
| PubMed: | View item in PubMed |
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