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| Item Type: | Article |
|---|---|
| Title: | Oligonucleotide library screening for identification of virus-specific T-cell receptors |
| Creators Name: | Welters, M.L. and Stadler, S. and Anastasopoulou, V. and Bullinger, L. and Leisegang, M. and Kammertöns, T. and Welters, C. and Hansmann, L. |
| Abstract: | We demonstrate an optimized oligonucleotide library-based approach for the identification of virus-reactive T-cell receptors using Epstein-Barr virus as an example. HEK293T served as antigen-presenting cells and were co-cultured with human T cells that were transduced with T-cell receptors in question. T-cell activation was detected by CD137 expression. |
| Keywords: | Epstein-Barr Virus, Oligonucleotide Library, Target Epitope Screening, T-Cell Immunology, TCR Antigen Identification |
| Source: | European Journal of Immunology |
| ISSN: | 0014-2980 |
| Publisher: | Wiley |
| Page Range: | e2350908 |
| Date: | 19 March 2024 |
| Official Publication: | https://doi.org/10.1002/eji.202350908 |
| PubMed: | View item in PubMed |
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