Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Sex-specific structural and functional cardiac remodeling during healthy aging assessed by cardiovascular magnetic resonance

[thumbnail of Original article]
Preview
PDF (Original article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB
[thumbnail of Supplemental Material] Other (Supplemental Material)
833kB

Item Type:Article
Title:Sex-specific structural and functional cardiac remodeling during healthy aging assessed by cardiovascular magnetic resonance
Creators Name:Grassow, L., Gröschel, J., Saad, H., Krüger, L.D., Kuhnt, J., Müller, M., Hadler, T., Blaszczyk, E. and Schulz-Menger, J.
Abstract:BACKGROUND: Aging as a major non-modifiable cardiac risk factor challenges future cardiovascular medicine and economic demands, which requires further assessments addressing physiological age-associated cardiac changes. OBJECTIVES: Using cardiovascular magnetic resonance (CMR), this study aims to characterize sex-specific ventricular adaptations during healthy aging. METHODS: The population included healthy volunteers who underwent CMR at 1.5 or 3 Tesla scanners applying cine-imaging with a short-axis coverage of the left (LV) and right (RV) ventricle. The cohort was divided by sex (female and male) and age (subgroups in years): 1 (19-29), 2 (30-39), 3 (40-49), and 4 (=50). Cardiac adaptations were quantitatively assessed by CMR indices. RESULTS: After the exclusion of missing or poor-quality CMR datasets or diagnosed disease, 140 of 203 volunteers were part of the final analysis. Women generally had smaller ventricular dimensions and LV mass, but higher biventricular systolic function. There was a significant age-associated decrease in ventricular dimensions as well as a significant increase in LV mass-to-volume ratio (LV-MVR, concentricity) in both sexes (LV-MVR in g/ml: age group 1 vs. 4: females 0.50 vs. 0.57, p=0.016, males 0.56 vs. 0.67, p=0.024). LV stroke volume index decreased significantly with age in both sexes, but stronger for men than for women (in ml/m(2): age group 1 vs. 4: females 51.76 vs. 41.94, p<0.001, males 55.31 vs. 40.78, p<0.001). Ventricular proportions (RV-to-LV-volume ratio) were constant between the age groups in both sexes. CONCLUSIONS: In both sexes, healthy aging was associated with an increase in concentricity and a decline in ventricular dimensions. Furthermore, relevant age-related sex differences in systolic LV performance were observed.
Keywords:Age, Women, Sex, Cardiac Physiology, Cardiac Risk Factor, Cardiovascular Magnetic Resonance
Source:Clinical Research in Cardiology
ISSN:1861-0684
Publisher:Springer
Date:11 March 2024
Official Publication:https://doi.org/10.1007/s00392-024-02430-5
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library