Synthesis of GTP-derived Ras ligands

Item Type:	Article
Title:	Synthesis of GTP-derived Ras ligands
Creators Name:	Soulère, L. and Aldrich, C. and Daumke, O. and Gail, R. and Kissau, L. and Wittinghofer, A. and Waldmann, H.
Abstract:	A practical and convenient method for the synthesis of acid- and base-sensitive GTP analogues carrying a further substituent at the terminal phosphate has been developed. Key to the successful synthesis of these potential ligands of the Ras protein is the use of Pd0-sensitive allyl protecting groups in a one-pot synthesis that avoids evaporation steps. Initial biochemical analysis of a representative compound revealed that such GTP analogues can bind to Ras and might open up the possibility of developing small molecules that can act as deactivators of oncogenic Ras.
Keywords:	Bioorganic Chemistry, Nucleotides, Protecting Groups, Ras Protein, Signal Transduction
Source:	ChemBioChem
ISSN:	1439-4227
Publisher:	Wiley-VCH
Volume:	5
Number:	10
Page Range:	1448-53
Date:	4 October 2004
Official Publication:	https://doi.org/10.1002/cbic.200400133
PubMed:	View item in PubMed

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