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| Item Type: | Review |
|---|---|
| Title: | Cellular senescence: Neither irreversible nor reversible |
| Creators Name: | Reimann, M. and Lee, S. and Schmitt, C.A. |
| Abstract: | Cellular senescence is a critical stress response program implicated in embryonic development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate cell-cycle exit mechanism. In analogy to replicative exhaustion of telomere-eroded cells, premature types of senescence-referring to oncogene-, therapy-, or virus-induced senescence-are widely considered irreversible growth arrest states as well. We discuss here that entry into full-featured senescence is not necessarily a permanent endpoint, but dependent on essential maintenance components, potentially transient. Unlike a binary state switch, we view senescence with its extensive epigenomic reorganization, profound cytomorphological remodeling, and distinctive metabolic rewiring rather as a journey toward a full-featured arrest condition of variable strength and depth. Senescence-underlying maintenance-essential molecular mechanisms may allow cell-cycle reentry if not continuously provided. Importantly, senescent cells that resumed proliferation fundamentally differ from those that never entered senescence, and hence would not reflect a reversion but a dynamic progression to a post-senescent state that comes with distinct functional and clinically relevant ramifications. |
| Keywords: | Aging, Apoptosis, Cell Cycle, Cell Division, Cellular Senescence, Pregnancy |
| Source: | Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Volume: | 221 |
| Number: | 4 |
| Page Range: | e20232136 |
| Date: | 1 April 2024 |
| Official Publication: | https://doi.org/10.1084/jem.20232136 |
| PubMed: | View item in PubMed |
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