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| Item Type: | Article |
|---|---|
| Title: | The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish |
| Creators Name: | Zaupa, M. and Nagaraj, N. and Sylenko, A. and Baier, H. and Sawamiphak, S. and Filosa, A. |
| Abstract: | Animals constantly need to judge the valence of an object in their environment: is it potential food or a threat? The brain makes fundamental decisions on the appropriate behavioral strategy by integrating external information from sensory organs and internal signals related to physiological needs. For example, a hungry animal may take more risks than a satiated one when deciding to approach or avoid an object. Using a proteomic profiling approach, we identified the Calmodulin-interacting peptide Pcp4a as a key regulator of foraging-related decisions. Food intake reduced abundance of protein and mRNA of pcp4a via dopamine D2-like receptor-mediated repression of adenylate cyclase. Accordingly, deleting the pcp4a gene made zebrafish larvae more risk averse in a binary decision assay. Strikingly, neurons in the tectum became less responsive to prey-like visual stimuli in pcp4a mutants, thus biasing the behavior toward avoidance. This study pinpoints a molecular mechanism modulating behavioral choice according to internal state. |
| Keywords: | Behavior, Decision-Making, Pcp4a, Tectum, Dopamine, Prey Capture, Escape, Hunger, Internal States, Animals, Zebrafish |
| Source: | Neuron |
| ISSN: | 0896-6273 |
| Publisher: | Cell Press |
| Volume: | 112 |
| Number: | 7 |
| Page Range: | 1150-1164.e6 |
| Date: | 3 April 2024 |
| Official Publication: | https://doi.org/10.1016/j.neuron.2024.01.001 |
| PubMed: | View item in PubMed |
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