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| Item Type: | Article |
|---|---|
| Title: | Gamma oscillation plasticity is mediated via parvalbumin interneurons |
| Creators Name: | Hadler, M.D. and Tzilivaki, A. and Schmitz, D. and Alle, H. and Geiger, J.R.P. |
| Abstract: | Understanding the plasticity of neuronal networks is an emerging field of (patho-) physiological research, yet the underlying cellular mechanisms remain poorly understood. Gamma oscillations (30 to 80 hertz), a biomarker of cognitive performance, require and potentiate glutamatergic transmission onto parvalbumin-positive interneurons (PVIs), suggesting an interface for cell-to-network plasticity. In ex vivo local field potential recordings, we demonstrate long-term potentiation of hippocampal gamma power. Gamma potentiation obeys established rules of PVI plasticity, requiring calcium-permeable AMPA receptors (CP-AMPARs) and metabotropic glutamate receptors (mGluRs). A microcircuit computational model of CA3 gamma oscillations predicts CP-AMPAR plasticity onto PVIs critically outperforms pyramidal cell plasticity in increasing gamma power and completely accounts for gamma potentiation. We reaffirm this ex vivo in three PVI-targeting animal models, demonstrating that gamma potentiation requires PVI-specific signaling via a Gq/PKC pathway comprising mGluR5 and a Gi-sensitive, PKA-dependent pathway. Gamma activity-dependent, metabotropically mediated CP-AMPAR plasticity on PVIs may serve as a guiding principle in understanding network plasticity in health and disease. |
| Keywords: | Hippocampus, Interneurons, Long-Term Potentiation, Neuronal Plasticity, Parvalbumins, Signal Transduction, Animals |
| Source: | Science Advances |
| ISSN: | 2375-2548 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 10 |
| Number: | 5 |
| Page Range: | eadj7427 |
| Date: | 2 February 2024 |
| Official Publication: | https://doi.org/10.1126/sciadv.adj7427 |
| PubMed: | View item in PubMed |
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