Helmholtz Gemeinschaft


Structure and function of the hippocampal CA3 module

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Article
Title:Structure and function of the hippocampal CA3 module
Creators Name:Sammons, R.P. and Vezir, M. and Moreno-Velasquez, L. and Cano, G. and Orlando, M. and Sievers, M. and Grasso, E. and Metodieva, V.D. and Kempter, R. and Schmidt, H. and Schmitz, D.
Abstract:The hippocampal formation is crucial for learning and memory, with submodule CA3 thought to be the substrate of pattern completion. However, the underlying synaptic and computational mechanisms of this network are not well understood. Here, we perform circuit reconstruction of a CA3 module using three dimensional (3D) electron microscopy data and combine this with functional connectivity recordings and computational simulations to determine possible CA3 network mechanisms. Direct measurements of connectivity schemes with both physiological measurements and structural 3D EM revealed a high connectivity rate, multi-fold higher than previously assumed. Mathematical modelling indicated that such CA3 networks can robustly generate pattern completion and replay memory sequences. In conclusion, our data demonstrate that the connectivity scheme of the hippocampal submodule is well suited for efficient memory storage and retrieval.
Keywords:Connectomics, CA3, Electron Microscopy, Pattern Completion, Memory
Source:Proceedings of the National Academy of Sciences of the United States of America
Publisher:National Academy of Sciences
Page Range:e2312281120
Date:6 February 2024
Official Publication:https://doi.org/10.1073/pnas.2312281120
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library