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| Item Type: | Article |
|---|---|
| Title: | Differentiation between Parkinson’s disease and the parkinsonian subtype of multiple system atrophy using the magnetic resonance T1w/T2w ratio in the middle cerebellar peduncle |
| Creators Name: | Wang, J. and Sugiyama, A. and Yokota, H. and Hirano, S. and Yamamoto, T. and Yamanaka, Y. and Araki, N. and Ito, S. and Paul, F. and Kuwabara, S. |
| Abstract: | Multiple system atrophy with predominant parkinsonism (MSA-P) can hardly be distinguished from Parkinson's disease (PD) clinically in the early stages. This study investigated whether a standardized T1-weighted/T2-weighted ratio (sT1w/T2w ratio) can effectively detect degenerative changes in the middle cerebellar peduncle (MCP) associated with MSA-P and PD and evaluated its potential to distinguish between these two diseases. We included 35 patients with MSA-P, 32 patients with PD, and 17 controls. T1w and T2w scans were acquired using a 1.5-T MR system. The MCP sT1w/T2w ratio was analyzed via SPM12 using a region-of-interest approach in a normalized space. The diagnostic performance of the MCP sT1w/T2w ratio was compared between the MSA-P, PD, and controls. Patients with MSA-P had significantly lower MCP sT1w/T2w ratios than patients with PD and controls. Furthermore, MCP sT1w/T2w ratios were lower in patients with PD than in the controls. The MCP sT1w/T2w ratio showed excellent or good accuracy for differentiating MSA-P or PD from the control (area under the curve (AUC) = 0.919 and 0.814, respectively) and substantial power for differentiating MSA-P from PD (AUC = 0.724). Therefore, the MCP sT1w/T2w ratio is sensitive in detecting degenerative changes in the MCP associated with MSA-P and PD and is useful in distinguishing MSA-P from PD. |
| Keywords: | Parkinson’s Disease, Multiple System Atrophy, Magnetic Resonance Imaging, Middle Cerebellar Peduncle |
| Source: | Diagnostics |
| ISSN: | 2075-4418 |
| Publisher: | MDPI |
| Volume: | 14 |
| Number: | 2 |
| Page Range: | 201 |
| Date: | January 2024 |
| Official Publication: | https://doi.org/10.3390/diagnostics14020201 |
| PubMed: | View item in PubMed |
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