Helmholtz Gemeinschaft


Renal extramedullary hematopoiesis in mast cell leukemia with bone marrow fibrosis

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Article
Title:Renal extramedullary hematopoiesis in mast cell leukemia with bone marrow fibrosis
Creators Name:Rieke, D.T. and Schmalbrock, L.K. and Ihlow, J. and Kleo, K. and von Brünneck, A.C. and Nolte, F. and Keller, U. and Ochsenreither, S.
Abstract:Systemic mastocytosis is defined by the clonal proliferation of abnormal mast cells. The clinical course can range from indolent forms with normal life expectancy to advanced mast cell leukemia with dismal prognosis. An association with other diseases, including myeloproliferative neoplasia, has been described. We present a case of a 75-year patient with a history of cutaneous mastocytosis who was diagnosed with mast cell leukemia more than 9 years ago and did not receive treatment. The patient presented to our clinic with acute kidney failure because of renal extramedullary hematopoiesis. Bone marrow histopathology revealed extensive fibrosis and 50% infiltration by mast cells with a c-KIT D816V mutation. No mutations supporting primary myelofibrosis were identified. Treatment with midostaurin was started, and the patient was discharged after improvement of renal function. Here, we discuss diagnostic challenges between different forms of mast cell leukemia and overlaps with other hematological malignancies.
Source:Case Reports in Hematology
Page Range:1-6
Date:3 January 2024
Official Publication:https://doi.org/10.1155/2024/3502887
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library