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| Item Type: | Article |
|---|---|
| Title: | Effects of a short-term vegan challenge in older adults on metabolic and inflammatory parameters - a randomized controlled crossover study |
| Creators Name: | Döschner, L. and Schulze, K. and Göger, L. and Bosy-Westphal, A. and Krüger, N. and Franz, K. and Müller-Werdan, U. and Herpich, C. and Norman, K. |
| Abstract: | SCOPE: A long-term vegan diet carries the risk of insufficient protein and micronutrient intake for older adults. However, even a short-term (48 h) vegan diet exerts positive metabolic effects in younger adults. In this study, we investigate the feasibility and effects of a short-term vegan challenge on metabolic and inflammatory markers in older adults. METHOD AND RESULTS: In this randomized controlled crossover-study, 30 healthy older adults (≥65 years) are assigned to either a 48 h ad libitum vegan or omnivorous diet. During the vegan diet, participants exhibit lower protein (p = 0.001) and fat intake as well as higher carbohydrate and dietary fiber intake, resulting in a lower caloric intake (all p < 0.001). Insulin concentrations (p = 0.042) and insulin resistance (p = 0.036) decline only after the vegan diet. The study observes reductions in serum glucose (p < 0.001), triglyceride (p = 0.005), and hsCRP (p = 0.044) concentrations and weight (p < 0.001), independent of the diet. Participants with low-grade inflammation exhibit notable metabolic improvements after the vegan diet. CONCLUSION: Improvements in insulin homeostasis are observed after the vegan diet, but meeting protein requirements are not feasible during the short-term vegan challenge despite dietary counseling, which warrants concern. |
| Keywords: | Aging, Inflammaging, Protein Source, Vegan Challenge |
| Source: | Molecular Nutrition & Food Research |
| ISSN: | 1613-4125 |
| Publisher: | Wiley |
| Volume: | 68 |
| Number: | 4 |
| Page Range: | e2300623 |
| Date: | February 2024 |
| Official Publication: | https://doi.org/10.1002/mnfr.202300623 |
| PubMed: | View item in PubMed |
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