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Mesenchymal cell migration on one-dimensional micropatterns

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Item Type:Review
Title:Mesenchymal cell migration on one-dimensional micropatterns
Creators Name:Heyn, J.C.J., Rädler, J.O. and Falcke, M.
Abstract:Quantitative studies of mesenchymal cell motion are important to elucidate cytoskeleton function and mechanisms of cell migration. To this end, confinement of cell motion to one dimension (1D) significantly simplifies the problem of cell shape in experimental and theoretical investigations. Here we review 1D migration assays employing micro-fabricated lanes and reflect on the advantages of such platforms. Data are analyzed using biophysical models of cell migration that reproduce the rich scenario of morphodynamic behavior found in 1D. We describe basic model assumptions and model behavior. It appears that mechanical models explain the occurrence of universal relations conserved across different cell lines such as the adhesion-velocity relation and the universal correlation between speed and persistence (UCSP). We highlight the unique opportunity of reproducible and standardized 1D assays to validate theory based on statistical measures from large data of trajectories and discuss the potential of experimental settings embedding controlled perturbations to probe response in migratory behavior.
Keywords:Cell Migration, Biophysics, Single Cell Dynamics, 1D, One-Dimension, Confinement, Micropattern, Mesenchymal
Source:Frontiers in Cell and Developmental Biology
ISSN:2296-634X
Publisher:Frontiers Media SA
Volume:12
Page Range:1352279
Date:16 April 2024
Official Publication:https://doi.org/10.3389/fcell.2024.1352279
PubMed:View item in PubMed

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