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DNA polymorphisms in adhesion molecule genes: a new risk factor for early atherosclerosis

Item Type:Article
Title:DNA polymorphisms in adhesion molecule genes: a new risk factor for early atherosclerosis
Creators Name:Wenzel, K. and Ernst, M. and Rohde, K. and Baumann, G. and Speer, A.
Abstract:To contribute to the analysis of the genetic background of atherosclerosis, especially endothelial dysfunction, we searched for DNA polymorphisms in the genes encoding E-, P-, and L-selectin, and ICAM-I and VCAM-I. We detected 17 mutations by single-strand conformation polymorphisms analysis and direct sequencing. Five of them resulted in an amino acid substitution. In E-selectin, exchanges from serine to arginine (position 128), from leucine to phenylalanine (position 554), and a DNA mutation from guanine to thymine (position 98) present significantly different allele frequencies in young patients with angiographically established, severe atherosclerosis, compared with an unselected population. Results suggest that these polymorphisms are associated with a higher risk for early severe atherosclerosis.
Keywords:Alleles, Arteriosclerosis, Base Sequence, DNA, DNA Primers, E-Selectin, Gene Frequency, Heterozygote Detection, Intercellular Adhesion Molecule-1, L-Selectin, P-Selectin, Point Mutation, Polymerase Chain Reaction, Risk Factors, Selectins, Single-Stranded Conformational Polymorphism, Vascular Cell Adhesion Molecule-1
Source:Human Genetics
Page Range:15-20
Date:1 January 1996
Official Publication:https://doi.org/10.1007/BF00218826
PubMed:View item in PubMed

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