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| Item Type: | Article |
|---|---|
| Title: | Cerebrospinal fluid findings in patients with neurological manifestations in post-COVID-19 syndrome |
| Creators Name: | Boesl, F. and Goereci, Y. and Gerhard, A. and Bremer, B. and Raeder, V. and Schweitzer, F. and Hoppmann, U. and Behrens, J. and Bellmann-Strobl, J. and Paul, F. and Wildemann, B. and Jarius, S. and Prüss, H. and Audebert, H.J. and Warnke, C. and Franke, C. |
| Abstract: | BACKGROUND: Information on cerebrospinal fluid (CSF) findings in patients with neurological manifestations in post-COVID-19 syndrome is scarce. METHODS: Retrospective evaluation of 84 CSF samples in patients fulfilling post-COVID-19 criteria in two neurological post-COVID-19 outpatient clinics. RESULTS: In 68% of samples, all CSF parameters were normal. The most frequent pathological CSF finding was elevation of total protein (median total protein 33.3 mg/dl [total range 18.5-116.2]) in 20 of 83 (24%) samples. The second most prevalent pathological finding was a blood-CSF barrier dysfunction as measured by elevation of QAlb (median QAlb 4.65 [2.4-13.2]) in 11/84 (13%). Pleocytosis was found in only 5/84 (6%) samples and was mild in all of them. CSF-restricted oligoclonal bands were found in 5/83 (6%) samples. Anti-neuronal autoantibodies in CSF were negative in most cases, whilst 12/68 (18%) samples were positive for anti-myelin autoantibodies in serum. PCR for herpesviridae (HSV-1/-2, VZV, EBV, CMV, HHV6) showed, if at all, only weakly positive results in CSF or EDTA whole blood/plasma. CONCLUSIONS: The majority of samples did not show any pathologies. The most frequent findings were elevation of total protein and blood-CSF barrier dysfunction with no signs of intrathecal inflammation. CSF analysis still keeps its value for exclusion of differential diagnoses. |
| Keywords: | Post-COVID, Long-COVID, Cerebrospinal Fluid, Blood-CSF Barrier Dysfunction, Neurology, Post-Acute Sequelae of SARS-CoV-2 Infection |
| Source: | Journal of Neurology |
| ISSN: | 0340-5354 |
| Publisher: | Springer |
| Volume: | 271 |
| Number: | 1 |
| Page Range: | 59-70 |
| Date: | January 2024 |
| Official Publication: | https://doi.org/10.1007/s00415-023-12092-4 |
| PubMed: | View item in PubMed |
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