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| Item Type: | Article |
|---|---|
| Title: | Male carriers of HLA-C*04:01 have increased risk of cardiac injury in COVID-19 |
| Creators Name: | Suwalski, P. and Violano, M. and Müller, M. and Patriki, D. and Thibeault, C. and Quedenau, C. and Wang, X. and Karadeniz, Z. and Saccomanno, J. and Doehn, J.M. and Hübner, R.H. and Hinzmann, B. and Beer, H.J. and Wiggli, B. and Siemann, S. and Suttorp, N. and Witzenrath, M. and Hippenstiel, S. and Skurk, C. and Poller, W. and Sander, L.E. and Kurth, F. and Borodina, T. and Guettouche, T. and Landmesser, U. and Heidecker, B. |
| Abstract: | Identification of factors that lead to the severe clinical course of COVID-19 is crucial for timely allocation of resources. The purpose of this study was to evaluate possible sex differences in cardiac injury associated with HLA-C*04:01. High sensitivity troponin T on admission (hs-TnTa) and maximum high sensitivity troponin T (hs-TnTmax) were used to assess for cardiac injury in patients with COVID-19 (n = 435). We tested for the association of elevated hs-TnT with HLA-C* 04:01 and evaluated for potential sex-specific differences. An association between hs-TnTa and the severity of clinical course was identified. In addition, our study revealed that hs-TnTmax was higher in men who were carriers of HLA-C*04:01 compared to men without the risk allele. Male carriers of HLA-C*04:01 with COVID-19 developed higher hs-TnTmax, suggesting a larger extent of cardiac injury. This association suggests the presence of different pathomechanisms in COVID-19 based on sex. |
| Keywords: | Genetic, HLA, HLA-C, HLA-C*04:01, COVID-19, Troponin T, hs-TnT |
| Source: | Journal of Cardiovascular Aging |
| ISSN: | 2768-5993 |
| Publisher: | OAE Publishing |
| Volume: | 2 |
| Number: | 3 |
| Page Range: | 33 |
| Date: | 27 June 2022 |
| Official Publication: | https://doi.org/10.20517/jca.2022.19 |
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