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| Item Type: | Article |
|---|---|
| Title: | AT1-AA infusion during pregnancy impairs CBF autoregulation postpartum |
| Creators Name: | Campbell, N. and Strong, L. and Fang, X. and Border, J.J. and Herrock, O. and Turner, T. and Deer, E. and Amaral, L. and Dechend, R. and Roman, R.J. and LaMarca, B. |
| Abstract: | Preeclampsia (PE), new-onset hypertension during pregnancy alongside organ dysfunction, is a leading cause of morbidity and mortality for the mother and fetus. PE women have activated B cells that produce agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA). AT1-AA impairs cerebral blood flow (CBF) autoregulation during pregnancy. Although AT1-AA often remains elevated up to 8 years postpartum, AT1-AA's effect on CBF autoregulation postpartum is unknown. This study examined whether elevated AT1-AA during pregnancy impairs CBF autoregulation postpartum and if this was augmented by infusion of AT1-AA postpartum. AT1-AA was infused into 12-week-old timed-pregnant Sprague Dawley rats beginning on gestational day 14. Uterine artery resistance index (UARI) was measured on gestational day 18 as a measure of endothelial dysfunction associated with PE. Dams were allowed to deliver. One group was given a second infusion of AT1-AA (50% perinatal dose mimicking levels observed in postpartum PE women) at 9 weeks postpartum. After postpartum week 10, mean arterial pressure (MAP) was measured in conscious rats and CBF autoregulation was measured by laser Doppler flowmetry. AT1-AA during pregnancy increased UARI (P<0.05). AT1-AA during pregnancy did not affect MAP postpartum but did impair CBF autoregulation postpartum. Infusion of AT1-AA postpartum significantly elevated blood pressure (P<0.01) but did not further impair CBF autoregulation. This study demonstrates that circulating AT1-AA during pregnancy causes impairment of CBF autoregulation well into the postpartum period indicating that elevated AT1-AA leads to long-term cerebrovascular consequences. Targeting AT1-AA may prevent cerebrovascular effects associated with PE during pregnancy and postpartum. |
| Keywords: | Autoantibodies, Blood Pressure, Cerebral Blood Flow, Inflammation, Preeclampsia, Animals, Rats |
| Source: | International Journal of Cerebrovascular Disease and Stroke |
| ISSN: | 2688-8734 |
| Publisher: | Gavin Publishers |
| Volume: | 6 |
| Number: | 1 |
| Page Range: | 154 |
| Date: | 17 July 2023 |
| Official Publication: | https://doi.org/10.29011/2688-8734.100154 |
| PubMed: | View item in PubMed |
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