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| Item Type: | Article |
|---|---|
| Title: | European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation |
| Creators Name: | Budu-Aggrey, A. and Kilanowski, A. and Sobczyk, M.K. and Shringarpure, S.S. and Mitchell, R. and Reis, K. and Reigo, A. and Mägi, R. and Nelis, M. and Tanaka, N. and Brumpton, B.M. and Thomas, L.F. and Sole-Navais, P. and Flatley, C. and Espuela-Ortiz, A. and Herrera-Luis, E. and Lominchar, J.V.T. and Bork-Jensen, J. and Marenholz, I. and Arnau-Soler, A. and Jeong, A. and Fawcett, K.A. and Baurecht, H. and Rodriguez, E. and Alves, A.C. and Kumar, A. and Sleiman, P.M. and Chang, X. and Medina-Gomez, C. and Hu, C. and Xu, C.J. and Qi, C. and El-Heis, S. and Titcombe, P. and Antoun, E. and Fadista, J. and Wang, C.A. and Thiering, E. and Wu, B. and Kress, S. and Kothalawala, D.M. and Kadalayil, L. and Duan, J. and Zhang, H. and Hadebe, S. and Hoffmann, T. and Jorgenson, E. and Choquet, H. and Risch, N. and Njølstad, P. and Andreassen, O.A. and Johansson, S. and Almqvist, C. and Gong, T. and Ullemar, V. and Karlsson, R. and Magnusson, P.K.E. and Szwajda, A. and Burchard, E.G. and Thyssen, J.P. and Hansen, T. and Kårhus, L.L. and Dantoft, T.M. and Jeanrenaud, A.C.S.N. and Ghauri, A. and Arnold, A. and Homuth, G. and Lau, S. and Nöthen, M.M. and Hübner, N. and Imboden, M. and Visconti, A. and Falchi, M. and Bataille, V. and Hysi, P. and Ballardini, N. and Boomsma, D.I. and Hottenga, J.J. and Müller-Nurasyid, M. and Ahluwalia, T.S. and Stokholm, J. and Chawes, B. and Schoos, A.M.M. and Esplugues, A. and Bustamante, M. and Raby, B. and Arshad, S. and German, C. and Esko, T. and Milani, L.A. and Metspalu, A. and Terao, C. and Abuabara, K. and Løset, M. and Hveem, K. and Jacobsson, B. and Pino-Yanes, M. and Strachan, D.P. and Grarup, N. and Linneberg, A. and Lee, Y. and Probst-Hensch, N. and Weidinger, S. and Jarvelin, M.R. and Melén, E. and Hakonarson, H. and Irvine, A.D. and Jarvis, D. and Nijsten, T. and Duijts, L. and Vonk, J.M. and Koppelmann, G.H. and Godfrey, K.M. and Barton, S.J. and Feenstra, B. and Pennell, C.E. and Sly, P.D. and Holt, P.G. and Williams, L.K. and Bisgaard, H. and Bønnelykke, K. and Curtin, J. and Simpson, A. and Murray, C. and Schikowski, T. and Bunyavanich, S. and Weiss, S.T. and Holloway, J.W. and Min, J.L. and Brown, S.J. and Standl, M. and Paternoster, L. |
| Abstract: | Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities. |
| Keywords: | Atopic Dermatitis, Black People, Genetic Predisposition to Disease, Genome-Wide Association Study, Hispanic or Latino, Single Nucleotide Polymorphism |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 14 |
| Number: | 1 |
| Page Range: | 6172 |
| Date: | 4 October 2023 |
| Official Publication: | https://doi.org/10.1038/s41467-023-41180-2 |
| PubMed: | View item in PubMed |
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