The contribution of the AT1 receptor to erythropoiesis

Item Type:	Review
Title:	The contribution of the AT1 receptor to erythropoiesis
Creators Name:	Rodrigues, A.F. and Bader, M.
Abstract:	The renin-angiotensin system (RAS) comprises a broad set of functional peptides and receptors that play a role in cardiovascular homeostasis and contribute to cardiovascular pathologies. Angiotensin II (Ang II) is the most potent peptide hormone produced by the RAS due to its high abundance and its strong and pleiotropic impact on the cardiovascular system. Formation of Ang II takes place in the bloodstream and additionally in tissues in the so-called local RAS. Of the two Ang II receptors (AT1 and AT2) that Ang II binds to, AT1 is the most expressed throughout the mammalian body. AT1 expression is not restricted to cells of the cardiovascular system but in fact AT1 protein is found in nearly all organs, hence, Ang II takes part in several modulatory physiological processes one of which is erythropoiesis. In this review, we present multiple evidence supporting that Ang II modulates physiological and pathological erythropoiesis processes trough the AT1 receptor. Cumulative evidence indicates that Ang II by three distinct mechanisms influences erythropoiesis: 1) stimulation of renal erythropoietin synthesis; 2) direct action on bone marrow precursor cells; and 3) modulation of sympathetic nerve activity to the bone marrow. The text highlights clinical and preclinical evidence focusing on mechanistic studies using rodent models.
Keywords:	Angiotensin II, Erythropoiesis, Renin-Angiotensin System, Type 1 Angiotensin Receptor, Type 2 Angiotensin Receptor, Animals, Mammals
Source:	Biochemical Pharmacology
ISSN:	0006-2952
Publisher:	Elsevier
Volume:	217
Page Range:	115805
Date:	November 2023
Official Publication:	https://doi.org/10.1016/j.bcp.2023.115805
PubMed:	View item in PubMed

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