Helmholtz Gemeinschaft


Maternal COVID-19 causing intrauterine foetal demise with microthrombotic placental insufficiency: a case report

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
[img] Other (Supporting Information)

Item Type:Article
Title:Maternal COVID-19 causing intrauterine foetal demise with microthrombotic placental insufficiency: a case report
Creators Name:Nonn, O. and Bonstingl, L. and Sallinger, K. and Neuper, L. and Fuchs, J. and Gauster, M. and Huppertz, B. and Brislinger, D. and El-Heliebi, A. and Fluhr, H. and Kampelmühler, E. and Klaritsch, P.
Abstract:BACKGROUND: Pregnant women have an increased risk of getting infected with SARS-CoV-2 and are more prone to severe illness. Data on foetal demise in affected pregnancies and its underlying aetiology is scarce and pathomechanisms remain largely unclear. CASE: Herein we present the case of a pregnant woman with COVID-19 and intrauterine foetal demise. She had no previous obstetric or gynaecological history, and presented with mild symptoms at 34 + 3 weeks and no signs of foetal distress. At 35 + 6 weeks intrauterine foetal death was diagnosed. In the placental histopathology evaluation, we found inter- and perivillous fibrin depositions including viral particles in areas of degraded placental anatomy without presence of viral entry receptors and SARS-CoV-2 infection of the placenta. CONCLUSION: This case demonstrates that maternal SARS-CoV-2 infection in the third trimester may lead to an unfavourable outcome for the foetus due to placental fibrin deposition in maternal COVID-19 disease possibly via a thrombogenic microenvironment, even when the foetus itself is not infected.
Keywords:SARS–CoV-2-Infection, COVID-19, Vertical Transmission, Intrauterine Foetal Death, In Situ Detection, Perivillous Fibrin Deposition and Chronic Placentitis, Pregnancy, Microthrombosis, Case Report
Source:BMC Pregnancy and Childbirth
Publisher:BioMed Central
Page Range:653
Date:9 September 2023
Official Publication:https://doi.org/10.1186/s12884-023-05942-6
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library