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Sodium as an important regulator of immunometabolism

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Item Type:Review
Title:Sodium as an important regulator of immunometabolism
Creators Name:Miyauchi, H. and Geisberger, S. and Luft, F.C. and Wilck, N. and Stegbauer, J. and Wiig, H. and Dechend, R. and Jantsch, J. and Kleinewietfeld, M. and Kempa, S. and Mueller, D.N.
Abstract:Salt sensitivity concerns blood pressure alterations after a change in salt intake (sodium chloride). The heart is a pump, and vessels are tubes; sodium can affect both. A high salt intake increases cardiac output, promotes vascular dysfunction and capillary rarefaction, and chronically leads to increased systemic vascular resistance. More recent findings suggest that sodium also acts as an important second messenger regulating energy metabolism and cellular functions. Besides endothelial cells and fibroblasts, sodium also affects innate and adaptive immunometabolism, immune cell function, and influences certain microbes and microbiota-derived metabolites. We propose the idea that the definition of salt sensitivity should be expanded beyond high blood pressure to cellular and molecular salt sensitivity.
Keywords:Macrophages, Mitochondria, Salts, Sodium, T Lymphocytes
Source:Hypertension
ISSN:0194-911X
Publisher:American Heart Association
Volume:81
Number:3
Page Range:426-435
Date:March 2024
Official Publication:https://doi.org/10.1161/hypertensionaha.123.19489
PubMed:View item in PubMed

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