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| Item Type: | Article |
|---|---|
| Title: | Similar neural pathways link psychological stress and brain-age in health and multiple sclerosis |
| Creators Name: | Schulz, M.A. and Hetzer, S. and Eitel, F. and Asseyer, S. and Meyer-Arndt, L. and Schmitz-Hübsch, T. and Bellmann-Strobl, J. and Cole, J.H. and Gold, S.M. and Paul, F. and Ritter, K. and Weygandt, M. |
| Abstract: | Clinical and neuroscientific studies suggest a link between psychological stress and reduced brain health in health and neurological disease but it is unclear whether mediating pathways are similar. Consequently, we applied an arterial-spin-labeling MRI stress task in 42 healthy persons and 56 with multiple sclerosis, and investigated regional neural stress responses, associations between functional connectivity of stress-responsive regions and the brain-age prediction error, a highly sensitive machine learning brain health biomarker, and regional brain-age constituents in both groups. Stress responsivity did not differ between groups. Although elevated brain-age prediction errors indicated worse brain health in patients, anterior insula–occipital cortex (healthy persons: occipital pole; patients: fusiform gyrus) functional connectivity correlated with brain-age prediction errors in both groups. Finally, also gray matter contributed similarly to regional brain-age across groups. These findings might suggest a common stress–brain health pathway whose impact is amplified in multiple sclerosis by disease-specific vulnerability factors. |
| Source: | iScience |
| ISSN: | 2589-0042 |
| Publisher: | Cell Press |
| Volume: | 26 |
| Number: | 9 |
| Page Range: | 107679 |
| Date: | 15 September 2023 |
| Official Publication: | https://doi.org/10.1016/j.isci.2023.107679 |
| PubMed: | View item in PubMed |
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