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Can single-cell and spatial omics unravel the pathophysiology of pre-eclampsia?

Item Type:Article
Title:Can single-cell and spatial omics unravel the pathophysiology of pre-eclampsia?
Creators Name:Hartmann, S. and Botha, S.M. and Gray, C.M. and Valdes, D.S. and Tong, S. and Kaitu’u-Lino, T.J. and Herse, F. and Bergman, L. and Cluver, C.A. and Dechend, R. and Nonn, O.
Abstract:Pre-eclampsia is a leading cause of maternal and fetal morbidity and mortality. Characterised by the onset of hypertension and proteinuria in the second half of pregnancy, it can lead to maternal end-organ injury such as cerebral ischemia and oedema, pulmonary oedema and renal failure, and potentially fatal outcomes for both mother and fetus. The causes of the different maternal end-organ phenotypes of pre-eclampsia and why some women develop pre-eclampsia condition early in pregnancy have yet to be elucidated. Omics methods include proteomics, genomics, metabolomics, transcriptomics. These omics techniques, previously mostly used on bulk tissue and individually, are increasingly available at a single cellular level and can be combined with each other. Multi-omics techniques on a single-cell or spatial level provide us with a powerful tool to understand the pathophysiology of pre-eclampsia. This review will explore the status of omics methods and how they can and could contribute to understanding the pathophysiology of pre-eclampsia.
Keywords:Pre-eclampsia, Single-Cell RNA-Seq, Multi-omics, Spatial Omics, Placenta
Source:Journal of Reproductive Immunology
Page Range:104136
Date:September 2023
Official Publication:https://doi.org/10.1016/j.jri.2023.104136
PubMed:View item in PubMed

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