|
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB | |
Other (Supplementary Data)
190kB |
Item Type: | Article |
---|---|
Title: | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis |
Creators Name: | Brune-Ingebretsen, S. and Høgestøl, E.A. and de Rosbo, N.K. and Berg-Hansen, P. and Brunborg, C. and Blennow, K. and Zetterberg, H. and Paul, F. and Uccelli, A. and Villoslada, P. and Harbo, H.F and Berge, T. |
Abstract: | Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS. |
Keywords: | Multiple Sclerosis, Serum Neurofilament Light Chain, Immune Cell Subset Frequencies, Biomarkers, Disease Worsening |
Source: | Journal of Neuroimmunology |
ISSN: | 0165-5728 |
Publisher: | Elsevier |
Volume: | 382 |
Page Range: | 578175 |
Date: | 15 September 2023 |
Official Publication: | https://doi.org/10.1016/j.jneuroim.2023.578175 |
PubMed: | View item in PubMed |
Repository Staff Only: item control page