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Association of helicobacter pylori positivity with risk of disease and mortality

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Item Type:Article
Title:Association of helicobacter pylori positivity with risk of disease and mortality
Creators Name:Wizenty, J. and Koop, P.H. and Clusmann, J. and Tacke, F. and Trautwein, C. and Schneider, K.M. and Sigal, M. and Schneider, C.V.
Abstract:BACKGROUND: Helicobacter pylori colonizes the human stomach. Infection causes chronic gastritis and increases the risk for gastroduodenal ulcer and gastric cancer. Its chronic colonization in the stomach triggers aberrant epithelial and inflammatory signals, that are also associated with systemic alterations. METHODS: Using PheWAS analysis in more than 8.000 participants in the community-based UK Biobank we explored the association of H. pylori positivity with gastric and extra gastric disease and mortality in a European country. RESULTS: Along with well-established gastric diseases we dominantly found overrepresented cardiovascular, respiratory, and metabolic disorders. Using multivariate analysis, the overall mortality of H. pylori positive participants was not altered, while the respiratory and COVID-19 associated mortality increased. Lipidomic analysis for H. pylori positive participants revealed a dyslipidemic profile with reduced HDL cholesterol and omega-3 fatty acids, which may represent a causative link between infection, systemic inflammation, and disease. CONCLUSION: Our study of H. pylori positivity demonstrates that it plays an organ- and disease entity-specific role in the development of human disease and highlight the importance of further research into the systemic effects of H. pylori infection.
Keywords:H. pylori, Mortality, Morbidity, Dyslipidemia, Gastric Cancer
Source:Clinical and Translational Gastroenterology
Publisher:Wolters Kluwer
Page Range:e00610
Date:September 2023
Official Publication:https://doi.org/10.14309/ctg.0000000000000610
PubMed:View item in PubMed

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