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Play and tickling responses map to the lateral columns of the rat periaqueductal gray

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Item Type:Article
Title:Play and tickling responses map to the lateral columns of the rat periaqueductal gray
Creators Name:Gloveli, N. and Simonnet, J. and Tang, W. and Concha-Miranda, M. and Maier, E. and Dvorzhak, A. and Schmitz, D. and Brecht, M.
Abstract:The persistence of play after decortication points to a subcortical mechanism of play control. We found that global blockade of the rat periaqueductal gray with either muscimol or lidocaine interfered with ticklishness and play. We recorded vocalizations and neural activity from the periaqueductal gray of young, playful rats during interspecific touch, play, and tickling. Rats vocalized weakly to touch and more strongly to play and tickling. Periaqueductal gray units showed diverse but strong modulation to tickling and play. Hierarchical clustering based on neuronal responses to play and tickling revealed functional clusters mapping to different periaqueductal gray columns. Specifically, we observed play-neutral/tickling-inhibited and tickling/play-neutral units in dorsolateral and dorsomedial periaqueductal gray columns. In contrast, strongly play/tickling-excited units mapped to the lateral columns and were suppressed by anxiogenic conditions. Optogenetic inactivation of lateral periaqueductal columns disrupted ticklishness and play. We conclude that the lateral periaqueductal gray columns are decisive for play and laughter.
Keywords:Play, Tickling, Midbrain, Periaqueductal Gray, Neuropixels, Laughter, Affective Neuroscience, Optogenetics, Vocalizations, Instinctive Behaviors, Animals, Rats
Publisher:Cell Press
Page Range:3041-3052
Date:4 October 2023
Official Publication:https://doi.org/10.1016/j.neuron.2023.06.018
PubMed:View item in PubMed

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