The potential of cross-linking mass spectrometry in the development of protein-protein interaction modulators

Item Type:	Article
Title:	The potential of cross-linking mass spectrometry in the development of protein-protein interaction modulators
Creators Name:	Ruwolt, M. and Piazza, I. and Liu, F.
Abstract:	Cross-linking mass spectrometry (XL-MS) can provide a wealth of information on endogenous protein-protein interaction (PPI) networks and protein binding interfaces. These features make XL-MS an attractive tool to support the development of PPI-targeting drugs. Though not yet widely used, applications of XL-MS to drug characterization are beginning to emerge. Here, we compare XL-MS to established structural proteomics methods in drug research, discuss the current state and remaining challenges of XL-MS technology, and provide a perspective on the future role XL-MS can play in drug development, with a particular emphasis on PPI modulators.
Keywords:	Mass Spectrometry, Cross-Linking, Protein–Protein Interactions, PROTAC, PPI modulator
Source:	Current Opinion in Structural Biology
ISSN:	0959-440X
Publisher:	Elsevier
Volume:	82
Page Range:	102648
Date:	October 2023
Official Publication:	https://doi.org/10.1016/j.sbi.2023.102648
PubMed:	View item in PubMed

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