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| Item Type: | Article |
|---|---|
| Title: | Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis |
| Creators Name: | Chen, J. and Alexander, T. and Walter-Rittel, T. and Ziagaki, A. and Siffrin, V. |
| Abstract: | Granulomatosis or eosinophilic granulomatosis with polyangiitis (GPA/EGPA) can affect multiple organs resulting in heterogeneous symptoms and phenotypes. Pituitary gland dysfunction rarely occurs in GPA (1–3%) and even less in EGPA (two case reports). Here, we report a case of a 51-year-old female patient with a four-year history of EGPA who presented with new polydipsia and polyuria. Laboratory testing and magnetic resonance imaging (MRI) confirmed pituitary gland dysfunction caused by a hypophysitis. Therapeutic adjustment with a switch from dupilumab to mepolizumab resulted in a decrease in clinical symptoms, inflammation in MRI, and normalization of C-reactive protein in serum. This case underlines hypophysitis as a rare organ involvement also in EGPA. Moreover, this case demonstrates the responsiveness of neuroinflammatory manifestations to the recently approved anti-interleukin-5 monoclonal antibody mepolizumab as a new potential treatment option. |
| Keywords: | Anti-IL5 Blockade, Case Report, Eosinophilic Granulomatosis with Polyangiitis, Bituitary Gland Dysfunction |
| Source: | Therapeutic Advances in Neurological Disorders |
| ISSN: | 1756-2856 |
| Publisher: | Sage Publications |
| Volume: | 16 |
| Page Range: | 17562864231182519 |
| Date: | 2023 |
| Official Publication: | https://doi.org/10.1177/17562864231182519 |
| PubMed: | View item in PubMed |
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