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| Item Type: | Article |
|---|---|
| Title: | Cardiovascular health-related quality of life in cancer: a prospective study comparing the ESC HeartQoL and EORTC QLQ-C30 questionnaire |
| Creators Name: | Anker, M.S., Potthoff, S.K., Lena, A., Porthun, J., Hadzibegovic, S., Evertz, R., Denecke, C., Fröhlich, A.K., Sonntag, F., Regitz-Zagrosek, V., Rosen, S.D., Lyon, A.R., Lüscher, T.F., Spertus, J.A., Anker, S.D., Karakas, M., Bullinger, L., Keller, U., Landmesser, U., Butler, J. and von Haehling, S. |
| Abstract: | AIMS: Health-related quality of life (HRQoL) is highly relevant in cancer and often assessed with the EORTC QLQ-C30. Cardiovascular HRQoL in cancer can be measured with the ESC HeartQoL questionnaire. We compared these instruments and examined their prognostic value. METHODS: Summary scores for EORTC QLQ-C30 (0-100 points) and HeartQoL (0-3 points) questionnaires were prospectively assessed in 290 patients with mostly advanced cancer (stage 3/4: 81%, 1-year mortality: 36%) and 50 healthy controls (similar age and sex). Additionally, physical function and activity assessments were performed. RESULTS: Both questionnaires demonstrated reduced HRQoL in patients with cancer vs controls (EORTC QLQ-C30: 67±20 vs 91±11, p<0.001; ESC HeartQoL: 1.8±0.8 vs 2.7±0.4, p<0.001). The instruments were strongly correlated with each other (summary scores (r=0.76), physical (r=0.81), and emotional subscales (r=0.75, all p<0.001)) and independently associated with all-cause mortality (best cut-offs: EORTC QLQ-C30 <82.69: hazard ratio (HR) 2.33, p=0.004, HeartQoL <1.50: HR 1.85, p=0.004 - adjusted for sex, age, left ventricular ejection fraction, NT-proBNP, hsTroponinT, cancer stage/type), with no differences in the strength of the association by sex (p-interaction>0.9). Combining both questionnaires identified three risk groups with highest mortality in patients below both cut-offs (vs. patients above both cut-offs: HR 3.60, p<0.001). Patients with results below both cut-offs, showed higher NT-proBNP and reduced physical function and activity. CONCLUSIONS: EORTC QLQ-C30 and ESC HeartQoL - assessing cancer and cardiovascular HRQoL - are both associated with increased mortality in cancer patients, with even greater stratification by combing both. Reduced HRQoL scores were associated with elevated cardiovascular biomarkers and decreased functional status. |
| Keywords: | Quality of Life, Patients with Cancer, EORTC QLQ-C30, HeartQoL |
| Source: | European Journal of Heart Failure |
| ISSN: | 1388-9842 |
| Publisher: | Elsevier |
| Volume: | 25 |
| Number: | 9 |
| Page Range: | 1635-1647 |
| Date: | September 2023 |
| Official Publication: | https://doi.org/10.1002/ejhf.2951 |
| PubMed: | View item in PubMed |
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